Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8t3k
Q-score: 0.418
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Heterodimeric bmrcd with ligands atp and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ATP: BmrCD_OC-ATP
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8fhk
Q-score: 0.454
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Magnesium ion (24 Da, Ligand)
- Heterodimeric bmrcd with ligands atp and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8fmv
Q-score: 0.489
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole (452 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Heterodimeric bmrcd with ht1, atp, mg2+ and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8szc
Q-score: 0.494
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole (452 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Magnesium ion (24 Da, Ligand)
- Heterodimeric bmrcd with ligands atp and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8t1p
Q-score: 0.526
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (67 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adp orthovanadate (544 Da, Ligand)
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (77 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Heterodimeric bmrcd with ligands atp/aov and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS
Nat Commun (2023) 14 pp. 7184-7184 [ Pubmed: 37938578 DOI: doi:10.1038/s41467-023-42937-5 ]
- Probable multidrug resistance abc transporter atp-binding/permease protein yheh (Protein from Bacillus subtilis subsp. subtilis str. 168)
- Probable multidrug resistance abc transporter atp-binding/permease protein yhei (Protein from Bacillus subtilis subsp. subtilis str. 168)
- Heterodimeric bmrcd with ligands atp/aov and lipids (Complex from Bacillus subtilis subsp. subtilis str. 168)
Structure of TRPC3 at 2.7 angstrom in high calcium state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7dxb
Q-score: 0.56
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
Structure of TRPC3 at 3.06 angstrom in low calcium state
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 7dxc
Q-score: 0.454
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
Structure of TRPC3 gain of function mutation R803C at 3.2 angstrom in 1340nM free calcium state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7dxe
Q-score: 0.51
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7dxf
Q-score: 0.515
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ Pubmed: 35051376 DOI: doi:10.1016/j.neuron.2021.12.023 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- [2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-[(3r,5s)-3,5-dimethylpiperidin-1-yl]methanone (359 Da, Ligand)
- Short transient receptor potential channel 6 (106 kDa, Protein from Homo sapiens)
- Human transient receptor potential channel 6 tetramer (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)